Why Choose TWO2® Therapy and What to Expect

Convenient and Easy-to-use:

TWO2® therapy is designed with you, the patient, in mind. You can use the therapy in your home while watching TV or reading a book. At the start of therapy, an AOTI representative will drop the equipment off at your home and teach you how to begin a therapy session. Our Patient Guide walks you through each of the steps in case you want a reminder after the representative leaves your home. If you have any questions or concerns, our representatives and customer service teams are just a phone call away.

Compatible with dressings and TCCs:

You can often wear your usual dressings and/or total contact casts (TCCs) underneath the Extremity Chamber (or “Boot”). Your doctor will tell you if your dressings are compatible with TWO2 therapy or if they must be removed before therapy.

Clinically Proven:

• Faster healing* ^1,2
• Reduces wound recurrence rates^1,2
• Prevents amputations and hospitalisations³
• Reduces pain²

*Compared to Standard of Care. Standard of Care for DFU includes offloading, dressing that provides a moist wound healing environment, exudate management and debridement of necrotic tissue. Standard of Care for VLU includes multi-layer gradient compression dressings, dressings that provide a moist wound healing environment, exudate management and debridement of necrotic tissue.

References:

1. 6X More likely to heal DFUs in 12 weeks, 6X Less likely DFUs recur at 12 months:
   Frykberg R, Franks P, et al. A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical Topical Wound Oxygen (TWO2) therapy in the treatment of chronic diabetic foot ulcers: the TWO2 study. Diabetes Care, 2020.
2. 2X Faster VLU healing, 87% Lower VLU recurrence rate at 36 months, Pain score dropped from 8 to 3 in 13 days:
   Tawfick WA, Sultan, S. Technical and Clinical Outcome of Topical Wound Oxygen in Comparison to Conventional Compression Dressings in the Management of Refractory Nonhealing Venous Ulcers. Vascular and Endovascular Surgery, 2012.
3. 88% Reduction in hospitalizations, 71% Reduction in amputations:
   Yellin J, et al. Reduced Hospitalizations and Amputations in Patients with Diabetic Foot Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy: Real-World Outcomes. Advances in Wound Care, 2021.